Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal disorders, with CIC affecting 11.7% of the global population and IBS-C affecting 1.3%. Despite their prevalence, many individuals do not seek medical treatment, and those who do often turn to primary care after trying lifestyle changes and over-the-counter remedies. This review offers a comprehensive overview of treatment strategies to help healthcare providers improve long-term outcomes for patients with CIC and IBS-C.

Patients with CIC and IBS-C often start with over-the-counter remedies such as fiber and osmotic laxatives, but they may not achieve adequate relief and may be hesitant to use prescription medications due to concerns about dependency. Dietary fiber supplementation, gut microbial alterations, and treatments like probiotics, prebiotics, and osmotic laxatives are commonly recommended, though their efficacy may vary. The review emphasizes the importance of a clinical treatment algorithm and the need for patient education to ensure proper treatment selection. In some cases, combination therapy may be necessary to optimize outcomes. A comprehensive, patient-centered approach, considering both lifestyle factors and the potential for combination treatments, is crucial for managing these complex conditions effectively.

Reference: Brenner DM, Harris LA, Chang CH, et al. Real-World Treatment Strategies to Improve Outcomes in Patients With Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation. Am J Gastroenterol. 2022 Apr 1;117(4S):S21-S26. doi: 10.14309/ajg.0000000000001709. PMID: 35354772.