This network meta-analysis aimed to compare the efficacy of secretagogues for treating irritable bowel syndrome with constipation (IBS-C) by evaluating randomized controlled trials (RCTs) published until June 2018....
Kathleen Ferrell,
DMSc, MPAS, PA-C
University of North Carolina, Chapel Hill
Secretagogues for IBS-C: Results from a Network Meta-analysis
This network meta-analysis evaluated the comparative efficacy and safety of secretagogues (linaclotide, lubiprostone, plecanatide, tenapanor) for treating IBS-C, analyzing data...
Linaclotide Significantly Improves Abdominal Symptoms in Patients With IBS-C
This randomized controlled trial investigated the effectiveness of linaclotide compared to placebo in reducing abdominal symptoms (bloating, discomfort, pain) in...
Antidepressants and Psychological Therapies Effective in Treating IBS
This updated systematic review and meta-analysis aimed to assess the effectiveness of antidepressants and psychological therapies in treating irritable bowel...
Amitriptyline Shows Significant Improvement in IBS Symptoms in Primary Care Setting
A multicenter, double-blind, placebo-controlled trial was conducted to determine if amitriptyline (10-30 mg nightly) is superior to placebo for improving...
