This network meta-analysis evaluated the comparative efficacy and safety of secretagogues (linaclotide, lubiprostone, plecanatide, tenapanor) for treating IBS-C, analyzing data from 15 randomized controlled trials involving 8,462 patients....
Linaclotide Significantly Improves Abdominal Symptoms in Patients With IBS-C
This randomized controlled trial investigated the effectiveness of linaclotide compared to placebo in reducing abdominal symptoms (bloating, discomfort, pain) in...
Antidepressants and Psychological Therapies Effective in Treating IBS
This updated systematic review and meta-analysis aimed to assess the effectiveness of antidepressants and psychological therapies in treating irritable bowel...
Amitriptyline Shows Significant Improvement in IBS Symptoms in Primary Care Setting
A multicenter, double-blind, placebo-controlled trial was conducted to determine if amitriptyline (10-30 mg nightly) is superior to placebo for improving...